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The whitening agent works by penetrating the enamel and oxidizing the pigmented molecules responsible for both nicotine stains on teeth and the shallower tar-derived discoloration that has infiltrated the enamel surface

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The potential effect modification by age group, alcohol consumption status, regular exercise, presence or absence of obesity, diabetes mellitus, hypertension, dyslipidemia, CKD, and proteinuria were evaluated through stratified analysis and interaction testing using a likelihood ratio test